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Enrofloxacin Injection 10%


Main Ingredient
Enrofloxacin

Characteristic
Colorless to pale yellow clarity liquid.

Pharmacological Action
Pharmacodynamics Enrofloxacin is a fluoroquinolone broad-spectrum bactericidal drug for animal. The product has good effect against Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysiphe graminis, Proteus marcescens, Serratia marcescens, Corynebacterium pyogenes, Bacteria, Staphylococcus aureus, mycoplasma, chlamydia, etc. The effect against Pseudomonas aeruginosa, Streptococcus, anaerobic bacteria was weak. The product has post antibiotic effects to sensitive bacteria. The antibacterial mechanism of this product is acting on the bacterial DNA cell gyrase, interfering with bacterial DNA replication, transcription and repair and recombination, the bacteria can not normal growth and reproduction and death.
Pharmacokinetics This product can be absorbed rapidly and completely by intramuscular injection, and the bioavailability of pigs and cows were 91.9%, 82%, respectively. Can be widely distributed in animal body, and can be into the organization and body fluid, in addition to cerebrospinal fluid. Nearly all tissues of drug concentrations were higher than plasma. Metabolism of the liver is mainly by removing ethyl group of the 7-piperazinyl ring to form ciprofloxacin, followed by oxidation and glucuronic acid binding. Mainly through the kidneys (renal tubular secretion and glomerular filtration) discharge, 15% to 50% of the prototype excreted by the urine. Half-life is quite different in different species of animals and different routes of administration, for intramuscular injection, the half-life in cow is 5.9 hours, 9.9 hours in horses, 1.5 to 4.5 hours in sheep, 4.6 hours in pigs.

Drug Interaction
1) This product has synergistic effect with aminoglycoside or broad-spectrum penicillin.
2) Ca2+ 、Mg2+ 、Fe3+ and Al3+ may have chelating reaction with this product and influence the absorption.
3) When combined with theophylline and caffeine, the plasma protein binding rate decreased, the concentration of theophylline and caffeine in blood increased abnormally, and even occurred theophylline poisoning symptoms.
4) This product has inhibitory effect on liver drug enzymes, reducing clearance rate of drugs that metabolize in live, increasing the blood concentrations of drugs.

Indication
For the treatment of bacterial diseases and mycoplasma infection in livestock and small animals that caused by sensitive bacteria, such as E. coli disease, Salmonella, Pasteurellosis, Actinobacillus pleuropneumoniae, mastitis, mycoplasma pneumonia, etc.

Usage & Dosage
Intramuscular injection: 0.025ml/kg bodyweight for cattle, sheep, pig; 0.025-0.05ml for dog, cat, rabbit. Once or twice a day, for two or three days.

Adverse Reaction
1) Result in young animal cartilage degeneration, affect the bone development and cause claudication and pain.
2) The reactions of the digestive system are vomiting, loss of appetite, diarrhea and so on.
3) Skin reactions are erythema, itching, urticaria and photosensitivity reactions.
4) Occasionally occur allergic reaction, ataxia, seizures in dogs and cats.

Precaution
1) The product is not suitable for horses and 8 weeks old dogs. 
2) Intramuscular injection of a transient irritation.
3) Has a potential excitatory effect on the central nervous system, induced seizures, epileptic dogs with caution.
4) Carnivore and renal dysfunction animals with caution, can be occasional crystallization of urine.

Withdrawal Period
14 days for cattle, sheep; 10 days for pig; 14 days for rabbit. 

Storage
Shading, sealed perseveration.


Package
100ml/bottle


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